Supportive Interaction Between Cell Survival Signaling and Angiocompetent Factors Enhances Donor Cell Survival and Promotes Angiomyogenesis for Cardiac Repair

Jiang, Shujia; Kh Haider, Husnain; Muhammad Idris, Niagara; Salim, Asmat; Ashraf, Muhammad

doi:10.1161/01.res.0000244687.97719.4f

Public

Supportive Interaction Between Cell Survival Signaling and Angiocompetent Factors Enhances Donor Cell Survival and Promotes Angiomyogenesis for Cardiac Repair

Published in Circulation Research • Sep 8, 2006

Authors:

Shujia Jiang

Husnain Kh Haider

Niagara Muhammad Idris

Abstract

Akt is a major cell survival and angiogenic mediator downstream of angiopoietin-1 (Ang-1)/Tie-2 signaling pathway. We hypothesize that transplantation of mesenchymal stem cells (MSCs) co-overexpressing Ang-1 and Akt lead to better prognosis. Ang-1 and Akt genes were adenovirally transduced into MSCs...

Subject

Protein kinase B

Mesenchymal stem cell

Transplantation

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