Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair.

S, Jiang; HKh, Haider; NM, Idris; A, Salim; M, Ashraf

doi:10.1161/01.res.0000244687.97719.4f

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Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair.

Shared by NobleBlocks on Sep 7, 2006 • 12:00 AM UTC

Authors:

Jiang S

Haider HKh

Idris NM

Abstract

Akt is a major cell survival and angiogenic mediator downstream of angiopoietin-1 (Ang-1)/Tie-2 signaling pathway. We hypothesize that transplantation of mesenchymal stem cells (MSCs) co-overexpressing Ang-1 and Akt lead to better prognosis. Ang-1 and Akt genes were adenovirally transduced into MSCs...

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