Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.

A, Peled; I, Petit; O, Kollet; M, Magid; T, Ponomaryov; T, Byk; A, Nagler; H, Ben-Hur; A, Many; L, Shultz; O, Lider; R, Alon; D, Zipori; T, Lapidot

doi:10.1126/science.283.5403.845

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Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.

Shared by NobleBlocks on Feb 1, 1999 • 12:00 AM UTC

Authors:

Peled A

Petit I

Kollet O

Abstract

Stem cell homing and repopulation are not well understood. The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 were found to be critical for murine bone marrow engraftment by human severe combined immunodeficient (SCID) repopulating stem cells. Treatment of human cells with an...

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