PDH-E1α Dephosphorylation and Activation in Human Skeletal Muscle During Exercise

Pilegaard, Henriette; B. Birk, Jesper; Sacchetti, Massimo; Mourtzakis, Marina; Grahame Hardie, D.; A. Stewart, G.; Darrell Neufer, P.; Saltin, Bengt; van Hall, Gerrit; F. P. Wojtaszewski, Jørgen

doi:10.2337/db06-0152

Public

PDH-E1α Dephosphorylation and Activation in Human Skeletal Muscle During Exercise

Published in Diabetes • Oct 25, 2006

Authors:

Henriette Pilegaard

Jesper B. Birk

Massimo Sacchetti

Abstract

To investigate pyruvate dehydrogenase (PDH)-E1alpha subunit phosphorylation and whether free fatty acids (FFAs) regulate PDH activity, seven subjects completed two trials: saline (control) and intralipid/heparin (intralipid). Each infusion trial consisted of a 4-h rest followed by a 3-h two-legged k...

Subject

Dephosphorylation

Pyruvate dehydrogenase complex

Phosphorylation

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