The antitumoral effect of endostatin and angiostatin is associated with a down‐regulation of vascular endothelial growth factor expression in tumor cells

Hajitou, Amin; Grignet‐Debrus, Christine; Devy, Laetitia; Berndt, Sarah; Blacher, Silvia; Deroanne, Christophe; Bajou, Khalid; Annie T. Fong, T.; Chiang, Yawen; Foidart, Jean‐Michel; Noël, Agnès

doi:10.1096/fj.02-0109fje

Public

The antitumoral effect of endostatin and angiostatin is associated with a down‐regulation of vascular endothelial growth factor expression in tumor cells

Published in The FASEB Journal • Sep 19, 2002

Authors:

Amin Hajitou

Christine Grignet‐Debrus

Laetitia Devy

Abstract

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by adenoviral vectors, reduced in vitro the neovessel formation in the mouse aortic ring assay by 85...

Subject

Angiostatin

Endostatin

Angiogenesis

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