Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome

Hearle, Nicholas; Schumacher, Valérie; H. Menko, Fred; Olschwang, Sylviane; A. Boardman, Lisa; J.P. Gille, Johan; J. Keller, Josbert; Marie Westerman, Anne; J. Scott, Rodney; Lim, Wendy; D. Trimbath, Jill; M. Giardiello, Francis; B. Gruber, Stephen; Johan A. Offerhaus, G.; W.M. de Rooij, Felix; Paul Wilson, J.H.; Hansmann, Anika; Möslein, Gabriela; Royer-Pokora, Brigitte; Vogel, Tilman; K.S. Phillips, Robin; D. Spigelman, Allan; S. Houlston, Richard

doi:10.1158/1078-0432.ccr-06-0083

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Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome

Shared by NobleBlocks on May 15, 2006 • 12:00 AM UTC

Authors:

Nicholas Hearle

Valérie Schumacher

Fred H. Menko

Abstract

Abstract Background: Although an increased cancer risk in Peutz-Jeghers syndrome is established, data on the spectrum of tumors associated with the disease and the influence of germ-line STK11/LKB1 (serine/threonine kinase) mutation status are limited. Experimental Design: We analyzed the incidence ...

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