Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome

Hearle, Nicholas; Schumacher, Valerié; H. Menko, Fred; Olschwang, Sylviane; A. Boardman, Lisa; J.P. Gille, Johan; J. Keller, Josbert; Marie Westerman, Anne; J. Scott, Rodney; Lim, Wendy; D. Trimbath, Jill; M. Giardiello, Francis; B. Gruber, Stephen; Johan A. Offerhaus, G.; W.M. de Rooij, Felix; H. P. Wilson, J.; Hansmann, Anika; Möslein, Gabriela; Royer‐Pokora, Brigitte; Vogel, Tilman; Phillips, Robin; D. Spigelman, Allan; S. Houlston, Richard

doi:10.1158/1078-0432.ccr-06-0083

Public

Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome

Published in Clinical Cancer Research • May 15, 2006

Authors:

Nicholas Hearle

Valerié Schumacher

Fred H. Menko

Abstract

BACKGROUND: Although an increased cancer risk in Peutz-Jeghers syndrome is established, data on the spectrum of tumors associated with the disease and the influence of germ-line STK11/LKB1 (serine/threonine kinase) mutation status are limited. EXPERIMENTAL DESIGN: We analyzed the incidence of cancer...

Subject

STK11

Peutz–Jeghers syndrome

Medicine

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