A multidrug resistance transporter from human MCF-7 breast cancer cells

Austin Doyle, L.; Yang, Weidong; V. Abruzzo, Lynne; Krogmann, Tammy; Gao, Yongming; K. Rishi, Arun; D. Ross, Douglas

doi:10.1073/pnas.95.26.15665

Public

A multidrug resistance transporter from human MCF-7 breast cancer cells

Published in Proceedings of the National Academy of Sciences • Dec 22, 1998

Authors:

L. Austin Doyle

Weidong Yang

Lynne V. Abruzzo

Abstract

MCF-7/AdrVp is a multidrug-resistant human breast cancer subline that displays an ATP-dependent reduction in the intracellular accumulation of anthracycline anticancer drugs in the absence of overexpression of known multidrug resistance transporters such as P glycoprotein or the multidrug resistance...

Subject

Abcg2

MCF-7

Daunorubicin

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