α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

R. Winslow, Ashley; Chen, Chien‐Wen; Corrochano, Silvia; Acevedo‐Arozena, Abraham; E. Gordon, David; A. Peden, Andrew; Lichtenberg, Maike; M. Menzies, Fiona; Ravikumar, Brinda; Imarisio, Sara; D. M. Brown, Steve; J. O’Kane, Cahir; C. Rubinsztein, David

doi:10.1083/jcb.201003122

Public

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

Published in The Journal of Cell Biology • Sep 20, 2010

Authors:

Ashley R. Winslow

Chien‐Wen Chen

Silvia Corrochano

Abstract

Parkinson's disease (PD) is characterized pathologically by intraneuronal inclusions called Lewy bodies, largely comprised of α-synuclein. Multiplication of the α-synuclein gene locus increases α-synuclein expression and causes PD. Thus, overexpression of wild-type α-synuclein is toxic. In this stud...

Subject

Autophagy

Biology

Cell biology

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