Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

Tsujikawa, Hiroshi; Kurotaki, Yoko; Fujimori, Toshihiko; Fukuda, Kazuhiko; Nabeshima, Yo‐ichi

doi:10.1210/me.2003-0048

Public

Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

Published in Molecular Endocrinology • Oct 7, 2003

Authors:

Hiroshi Tsujikawa

Yoko Kurotaki

Toshihiko Fujimori

Abstract

The klotho gene encodes a novel type I membrane protein of beta-glycosidase family and is expressed principally in distal tubule cells of the kidney and choroid plexus in the brain. These mutants displayed abnormal calcium and phosphorus homeostasis together with increased serum 1,25-(OH)2D. In kl-/...

Subject

Klotho

Internal medicine

Endocrinology

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