Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy.

D, Portevin; M, Poupot; O, Rolland; CO, Turrin; JJ, Fournié; JP, Majoral; AM, Caminade; R, Poupot

doi:10.1186/1479-5876-7-82

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Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy.

Shared by NobleBlocks on Sep 24, 2009 • 12:00 AM UTC

Authors:

Portevin D

Poupot M

Rolland O

Abstract

Background Adoptive cell therapy with allogenic NK cells constitutes a promising approach for the treatment of certain malignancies. Such strategies are currently limited by the requirement of an efficient protocol for NK cell expansion. We have developed a method using synthetic nanosized phosphona...

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