Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

K. Kennedy, Mary; Glaccum, Moira; N. Brown, Sandra; Butz, Eric; L. Viney, Joanne; E. Embers, Monica; Matsuki, Naoto; Charrier, K; M. Sedger, Lisa; R. Willis, Cynthia; Brasel, Kenneth; Morrissey, Philip; L. Stocking, Kim; C. L. Schuh, JoAnn; Joyce, Sebastian; J. Peschon, Jacques

doi:10.1084/jem.191.5.771

Public

Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

Published in The Journal of Experimental Medicine • Feb 28, 2000

Authors:

Mary K. Kennedy

Moira Glaccum

Sandra N. Brown

Abstract

C57BL/6 mice genetically deficient in interleukin 15 (IL-15(-/-) mice) were generated by gene targeting. IL-15(-/-) mice displayed marked reductions in numbers of thymic and peripheral natural killer (NK) T cells, memory phenotype CD8(+) T cells, and distinct subpopulations of intestinal intraepithe...

Subject

Biology

Immunology

CD8

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