Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

K. Kennedy, Mary; Glaccum, Moira; N. Brown, Sandra; A. Butz, Eric; L. Viney, Joanne; Embers, Monica; Matsuki, Naoto; Charrier, Keith; Sedger, Lisa; R. Willis, Cynthia; Brasel, Kenneth; J. Morrissey, Philip; Stocking, Kim; C. L. Schuh, JoAnn; Joyce, Sebastian; J. Peschon, Jacques

doi:10.1084/jem.191.5.771

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Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

Shared by NobleBlocks on Feb 28, 2000 • 12:00 AM UTC

Authors:

Mary K. Kennedy

Moira Glaccum

Sandra N. Brown

Abstract

C57BL/6 mice genetically deficient in interleukin 15 (IL-15−/− mice) were generated by gene targeting. IL-15−/− mice displayed marked reductions in numbers of thymic and peripheral natural killer (NK) T cells, memory phenotype CD8+ T cells, and distinct subpopulations of intestinal intraepithelial l...

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