Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Galon, Jérôme; Costes, Anne; Sánchez‐Cabo, Fátima; Kirilovsky, Amos; Mlecnik, Bernhard; Lagorce-Pagès, Christine; Tosolini, Marie; Camus, Matthieu; Berger, Anne; Wind, Philippe; Zinzindohoué, Franck; Bruneval, Patrick; Cugnenc, Paul‐Henri; Trajanoski, Zlatko; H. Fridman, Wolf; Pagès, Franck

doi:10.1126/science.1129139

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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Published in Science • Sep 28, 2006

Authors:

Jérôme Galon

Anne Costes

Fátima Sánchez‐Cabo

Abstract

The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectiv...

Subject

Immune system

Colorectal cancer

Immunohistochemistry

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