Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

Gazzerro, Elisabetta; Gangji, Valérie; Canalis, Ernesto

doi:10.1172/jci3459

Public

Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

Published in Journal of Clinical Investigation • Dec 15, 1998

Authors:

Elisabetta Gazzerro

Valérie Gangji

Ernesto Canalis

Abstract

Bone morphogenetic proteins (BMPs) induce the differentiation of cells of the osteoblastic lineage and enhance the function of the osteoblast. Growth factors are regulated by binding proteins, but there is no information about binding proteins for BMPs in skeletal cells. Noggin specifically binds BM...

Subject

Noggin

Bone morphogenetic protein

Bone morphogenetic protein 2

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