Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.

Koyanagi-Aoi, Michiyo; Ohnuki, Mari; Takahashi, Kazutoshi; Okita, Keisuke; Noma, Hisashi; Sawamura, Yuka; Teramoto, Ito; Narita, Megumi; Sato, Yoshiko; Ichisaka, Tomoko; Amano, Naoki; Watanabe, Akira; Morizane, Asuka; Yamada, Yasuhiro; Sato, Tosiya; Takahashi, Jun; Yamanaka, Shinya

doi:10.1073/pnas.1319061110

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Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.

Shared by NobleBlocks on Dec 17, 2013 • 12:00 AM UTC

Authors:

Michiyo Koyanagi-Aoi

Mari Ohnuki

Kazutoshi Takahashi

Abstract

We examined the gene expression and DNA methylation of 49 human induced pluripotent stem cells (hiPSCs) and 10 human embryonic stem cells and found overlapped variations in gene expression and DNA methylation in the two types of human pluripotent stem cell lines. Comparisons of the in vitro neural d...

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