Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

O. Kilpeläinen, Tuomas; Qi, Lu; Brage, Søren; J. Sharp, Stephen; Sonestedt, Emily; W. Demerath, Ellen; Ahmad, Tariq; Mora, Samia; Kaakinen, Marika; H. Sandholt, Camilla; Holzapfel, Christina; S. Autenrieth, Christine; Hyppönen, Elina; Cauchi, Stéphane; He, Meian; Kutalik, Zoltán; Kumari, Meena; Stančáková, Alena; Meidtner, Karina; Balkau, Beverley; T. Tan, Jonathan; Mangino, Massimo; J. Timpson, Nicholas; Song, Yiqing; Carola Zillikens, M.; A. Jablonski, Kathleen; E. Garcia, Melissa; Johansson, Stefan; L. Bragg‐Gresham, Jennifer; Wu, Ying; V. van Vliet‐Ostaptchouk, Jana; Charlotte Onland‐Moret, N.; Zimmermann, Esther; V. Rivera, Natalia; Tanaka, Toshiko; M. Stringham, Heather; Silbernagel, Günther; Kanoni, Stavroula; F. Feitosa, Mary; Snitker, Søren; R. Ruiz, Jonatan; Metter, Jeffery; Teresa Martínez Larrad, Maria; Atalay, Mustafa; Hakanen, Maarit; Amin, Najaf; Cavalcanti-Proença, Christine; Grøntved, Anders; Hallmans, Göran; Jansson, John-Olov; Kuusisto, Johanna; Kähönen, Mika; L. Lutsey, Pamela; J. Nolan, John; Palla, Luigi; Pedersen, Oluf; Përusse, Louis; Renström, Frida; A. Scott, Robert; Shungin, Dmitry; Sovio, Ulla; Tammelin, Tuija; Rönnemaa, Tapani; A. Lakka, Timo; Uusitupa, Matti; Serrano‐Ríos, Manuel; Ferrucci, Luigi; Bouchard, Claude; Meirhaeghe, Aline; Fu, Mao; Walker, Mark; B. Borecki, Ingrid; Dedoussis, George; Fritsche, Andreas; Ohlsson, Claes; Boehnke, Michael; Bandinelli, Stefania; M. van Duijn, Cornelia; Ebrahim, Shah; A. Lawlor, Debbie; Guðnason, Vilmundur; B. Harris, Tamara; I. A. Sørensen, Thorkild; L. Mohlke, Karen; Hofman, Albert; G. Uitterlinden, André; Tuomilehto, Jaakko; Lehtimäki, Terho; T. Raitakari, Olli; Isomaa, Bo; R. Njølstad, Pål; C. Florez, José; Liu, Simin; Ness, Andy; D. Spector, Timothy; Shyong Tai, E; Froguel, Philippe; Boeing, Heiner; Laakso, Markku; Marmot, Michael; Bergmann, Sven; Power, Chris; Khaw, Kay‐Tee; I. Chasman, Daniel; M. Ridker, Paul; Hansen, Torben; L. Monda, Keri; Illig, Thomas; Järvelin, Marjo‐Riitta; J. Wareham, Nicholas; B. Hu, Frank; Groop, Leif; Orho‐Melander, Marju; Ekelund, Ulf; W. Franks, Paul; J. F. Loos, Ruth

doi:10.1371/journal.pmed.1001116

Public

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

Published in PLoS Medicine • Nov 1, 2011

Authors:

Tuomas O. Kilpeläinen

Lu Qi

Søren Brage

Abstract

BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambigu...

Subject

Meta-analysis

Obesity

Physical activity

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