Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

P. Chao, Mark; Jaiswal, Siddhartha; Weissman-Tsukamoto, Rachel; A. Alizadeh, Ash; J. Gentles, Andrew; Volkmer, Jens; Weiskopf, Kipp; B. Willingham, Stephen; Raveh, Tal; Y. Park, Christopher; Majeti, Ravindra; L. Weissman, Irving

doi:10.1126/scitranslmed.3001375

Public

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

Published in Science Translational Medicine • Dec 22, 2010

Authors:

Mark P. Chao

Siddhartha Jaiswal

Rachel Weissman-Tsukamoto

Abstract

Under normal physiological conditions, cellular homeostasis is partly regulated by a balance of pro- and anti-phagocytic signals. CD47, which prevents cancer cell phagocytosis by the innate immune system, is highly expressed on several human cancers including acute myeloid leukemia, non-Hodgkin's ly...

Subject

Calreticulin

CD47

Phagocytosis

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