Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

Marty, Bérengère; Maire, Virginie; Gravier, Eléonore; Rigaill, Guillem; Vincent‐Salomon, Anne; Käppler, Marion; Lebigot, Ingrid; Djelti, Fathia; Tourdès, Audrey; Gestraud, Pierre; Hupé, Philippe; Barillot, Emmanuel; Cruzalegui, Francisco; C. Tucker, Gordon; Stern, Marc‐Henri; Paul Thiery, Jean; A. Hickman, John; Dubois, Thierry

doi:10.1186/bcr2204

Public

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

Published in Breast Cancer Research • Dec 3, 2008

Authors:

Bérengère Marty

Virginie Maire

Eléonore Gravier

Abstract

INTRODUCTION: Basal-like carcinomas (BLCs) and human epidermal growth factor receptor 2 overexpressing (HER2+) carcinomas are the subgroups of breast cancers that have the most aggressive clinical behaviour. In contrast to HER2+ carcinomas, no targeted therapy is currently available for the treatmen...

Subject

PTEN

Surgical oncology

Breast cancer

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