Efficacy and Safety of Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage

A. Mayer, Stephan; C. Brun, Nikolai; Begtrup, Kamilla; Broderick, Joseph; M. Davis, Stephen; N. Diringer, Michael; E. Skolnick, Brett; Steiner, Thorsten

doi:10.1056/nejmoa0707534

Public

Efficacy and Safety of Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage

Published in New England Journal of Medicine • May 14, 2008

Authors:

Stephan A. Mayer

Nikolai C. Brun

Kamilla Begtrup

Abstract

BACKGROUND: Intracerebral hemorrhage is the least treatable form of stroke. We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes. METHODS: We randomly assigned 841 p...

Subject

Medicine

Intracerebral hemorrhage

Modified Rankin Scale

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