Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

McCabe, Nuala; C. Turner, Nicholas; J. Lord, Christopher; Kluzek, Katarzyna; Białkowska, Aneta; Swift, Sally; Giavara, Sabrina; J. O’Connor, Mark; Tutt, Andrew; Z. Zdzienicka, Małgorzata; C.M. Smith, Graeme; Ashworth, Alan

doi:10.1158/0008-5472.can-06-0140

Public

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

Published in Cancer Research • Aug 15, 2006

Authors:

Nuala McCabe

Nicholas C. Turner

Christopher J. Lord

Abstract

Deficiency in either of the breast cancer susceptibility proteins BRCA1 or BRCA2 induces profound cellular sensitivity to the inhibition of poly(ADP-ribose) polymerase (PARP) activity. We hypothesized that the critical role of BRCA1 and BRCA2 in the repair of double-strand breaks by homologous recom...

Subject

RAD51

FANCA

Poly ADP ribose polymerase

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