The <i>GPR54</i> Gene as a Regulator of Puberty

B. Seminara, Stephanie; Messager, Sophie; E. Chatzidaki, Emmanouella; R. Thresher, Rosemary; S. Acierno, James; K. Shagoury, Jenna; Bo-Abbas, Yøusef; Kuohung, Wendy; M. Schwinof, Kristine; G. Hendrick, Alan; Zahn, Dirk; Dixon, John; B. Kaiser, Ursula; A. Slaugenhaupt, Susan; F. Gusella, James; O’Rahilly, Stephen; Carlton, Mark; F. Crowley, William; Aparício, Samuel; H Colledge, William

doi:10.1056/nejmoa035322

Public

The GPR54 Gene as a Regulator of Puberty

Published in New England Journal of Medicine • Oct 22, 2003

Authors:

Stephanie B. Seminara

Sophie Messager

Emmanouella E. Chatzidaki

Abstract

BACKGROUND: Puberty, a complex biologic process involving sexual development, accelerated linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus. We conducted studies in humans and mice to identify the genetic factors that de...

Subject

Hypogonadotropic hypogonadism

Endocrinology

Internal medicine

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