Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

Mikita, Joanna; Dubourdieu-Cassagno, Nadège; S. A. Deloire, Mathilde; Vekris, Antoine; Biran, Marc; Raffard, Gérard; Brochet, Bruno; Canron, Marie‐Hélène; Franconi, Jean‐Michel; Boiziau, Claudine; G. Petry, Klaus

doi:10.1177/1352458510379243

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Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

Shared by NobleBlocks on Sep 2, 2010 • 12:00 AM UTC

Authors:

Joanna Mikita

Nadège Dubourdieu-Cassagno

Mathilde S. A. Deloire

Abstract

OBJECTIVES: We investigated proinflammatory M1 and immunomodulatory M2 activation profiles of circulating monocytes in relapsing experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, and tested whether altered M1/M2 equilibrium promotes CNS inflammation. RESULTS: Approaches of...

Subject

Experimental autoimmune encephalomyelitis

Multiple sclerosis

Medicine

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