Neurodegenerative and Neuroprotective Effects of Tumor Necrosis Factor (TNF) in Retinal Ischemia: Opposite Roles of TNF Receptor 1 and TNF Receptor 2

Fontaine, Valérie; Mohand‐Saïd, Saddek; Hanoteau, Noëlle; Fuchs, Céline; Pfizenmaier, Klaus; Eisel, Ulrich

doi:10.1523/jneurosci.22-07-j0001.2002

Public

Neurodegenerative and Neuroprotective Effects of Tumor Necrosis Factor (TNF) in Retinal Ischemia: Opposite Roles of TNF Receptor 1 and TNF Receptor 2

Published in Journal of Neuroscience • Apr 1, 2002

Authors:

Valérie Fontaine

Saddek Mohand‐Saïd

Noëlle Hanoteau

Abstract

Tumor necrosis factor (TNF) is an important factor in various acute and chronic neurodegenerative disorders. In retinal ischemia, we show early, transient upregulation of TNF, TNF receptor 1 (TNF-R1), and TNF-R2 6 hr after reperfusion preceding neuronal cell loss. To assess the specific role of TNF ...

Subject

Neuroprotection

Tumor necrosis factor alpha

Neurodegeneration

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!