Studies on stereoselective separations of the "azole'' antifungal drugs ketoconazole and itraconazole using HPLC and SFC on silica-based polysaccharides

Thienpont, A.; Gál, J.; Aeschlimann, C.; Félix, G.

doi:10.1051/analusis:1999270713

Public

Studies on stereoselective separations of the "azole'' antifungal drugs ketoconazole and itraconazole using HPLC and SFC on silica-based polysaccharides

Shared by NobleBlocks on Oct 1, 1999 • 12:00 AM UTC

Authors:

A. Thienpont

J. Gál

C. Aeschlimann

Abstract

The resolution of ketoconazole and itraconazole enantiomers has been studied in HPLC and SFC on chiral stationary phases based upon substituted polysaccharides with different groups such as 3,5-dimethylphenylcarbamates and (R)-phenylethylcarbamate. The separations have been studied particularly in S...

Subject

Ketoconazole

Itraconazole

Azole

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