A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

David Carmona, F.; Mackie, Sarah; Martín, Jose‐Ezequiel; Taylor, John; Vaglio, Augusto; Eyre, Stephen; Bossini‐Castillo, Lara; Castañeda, Santos; C. Cid, María; Hernández‐Rodríguez, José; Prieto‐González, Sergio; Solans, Roser; Ramentol-Sintas, Marc; González-Escribano, Marı́a-Francisca; Ortiz‐Fernández, Lourdes; C. Morado, Inmaculada; Narváez, Javier; A. Miranda‐Filloy, José; Beretta, Lorenzo; Lunardi, Claudio; A. Cimmino, Marco; Gianfreda, Davide; Santilli, Daniele; A. Ramirez, Giuseppe; Soriano, Alessandra; Muratore, Francesco; Pazzola, Giulia; Addimanda, Olga; Wijmenga, Cisca; Witte, Torsten; Henrik Schirmer, Jan; Moosig, Frank; Schönau, Verena; Franke, André; Palm, Øyvind; Molberg, Øyvind; P. Diamantopoulos, Andreas; Carette, Simon; Cuthbertson, David; Forbess, Lindsy; S. Hoffman, Gary; Khalidi, Nader; L. Koening, Curry; A. Langford, Carol; A. McAlear, Carol; W. Moreland, Larry; A. Monach, Paul; Pagnoux, Christian; Seo, Philip; Spiera, Robert; G. Sreih, Antoine; J. Warrington, Kenneth; R. Ytterberg, Steven; K. Gregersen, Peter; Pease, Colin; Gough, Andrew; R. Green, Michael; Hordon, Lesley; Jarrett, Stephen; A. Watts, Richard; Levy, Sarah; Patel, Yusuf; Kamath, Sanjeet; DasGupta, Bhaskar; Worthington, Jane; P. C. Koeleman, Bobby; I. W. de Bakker, Paul; H. Barrett, Jennifer; Salvarani, Carlo; A. Merkel, Peter; Á. González‐Gay, Miguel; W Morgan, Ann; Martı́n, Javier; Martínez-Berriochoa, Agustín; Unzurrunzaga, Ainhoa; Hidalgo-Conde, Ana; Belén Madroñero-Vuelta, Ana; Fernández‐Nebro, Antonio; Carmen Ordóñez-Cañizares, M.; Escalante, B.; Marí-Alfonso, Begoña; Sopeña, B.; Magro, César; Raya, Enrique; Grau, Elena; A. Ruiz San Román, José; de Miguel, Eugenio; López-Longo, FJ; Martínez, Lina; Gómez‐Vaquero, Carmen; Fernández‐Gutiérrez, Benjamín; Rodríguez‐Rodríguez, Luis; Bernardino Díaz-López, J.; Caminal‐Montero, Luis; Martínez Zapico, Aleida; Monfort, Jordi; Tío, Laura; Sánchez-Martín, Julio; José Alegre Sancho, Juan; Sáez-Comet, Luís; Pérez-Conesa, Mercedes; Corbera‐Bellalta, Marc; Jesús García-Villanueva, María; Fernández-Contreras, M.E.; Sánchez‐Pernaute, Olga; Blanco, Ricardo; Ortego‐Centeno, Norberto; Ríos-Fernández, Raquel; Luís Callejas-Rubio, José; Fanlo-Mateo, P.; Martínez‐Taboada, Víctor

doi:10.1016/j.ajhg.2015.02.009

Public

A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

Published in The American Journal of Human Genetics • Apr 1, 2015

Authors:

F. David Carmona

Sarah Mackie

Jose‐Ezequiel Martín

Abstract

We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and 15,306 unrelated control subjects from six different countries of European ancestry, was genotyped by the Immunochip a...

Subject

Human leukocyte antigen

Giant cell arteritis

Scale (ratio)

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