Analysis of σ
                    <sup>32</sup>
                    mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response

Yura, Takashi; Guisbert, Eric; Poritz, Mark; Zen Lu, Chi; Campbell, Elizabeth; A. Gross, Carol

doi:10.1073/pnas.0708819104

Public

Analysis of σ 32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response

Shared by NobleBlocks on Nov 6, 2007 • 12:00 AM UTC

Authors:

Takashi Yura

Eric Guisbert

Mark Poritz

Abstract

Protein quality control is accomplished by inducing chaperones and proteases in response to an altered cellular folding state. In Escherichia coli , expression of chaperones and proteases is positively regulated by σ 32 . Chaperone-mediated negative feedback control of σ 32 activity allows this tran...

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