Analysis of σ 32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response

Yura, Takashi; Guisbert, Eric; A. Poritz, Mark; Zen Lu, Chi; A. Campbell, Elizabeth; A. Gross, Carol

doi:10.1073/pnas.0708819104

Public

Analysis of σ 32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response

Published in Proceedings of the National Academy of Sciences • Oct 29, 2007

Authors:

Takashi Yura

Eric Guisbert

Mark A. Poritz

Abstract

Protein quality control is accomplished by inducing chaperones and proteases in response to an altered cellular folding state. In Escherichia coli, expression of chaperones and proteases is positively regulated by sigma32. Chaperone-mediated negative feedback control of sigma32 activity allows this ...

Subject

Chaperone (clinical)

GroEL

Proteases

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