Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope.

Tobin, Gerard; Thunberg, Ulf; Johnson, Anna; Eriksson, Inger; Söderberg, Ola; Karlsson, Karin; Merup, Mats; Juliusson, Gunnar; Vilpo, Juhani; Enblad, Gunilla; Sundström, Christer; Roos, Göran; Rosenquist, Richard

doi:10.1182/blood-2002-11-3485

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Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope.

Shared by NobleBlocks on Jun 15, 2003 • 12:00 AM UTC

Authors:

Gerard Tobin

Ulf Thunberg

Anna Johnson

Abstract

The immunoglobulin variable heavy chain (IgVH) gene mutation status is an important prognostic factor in chronic lymphocytic leukemia (CLL), since cases with mutated VH genes show significantly longer survival than unmutated cases. Recently, we reported a preferential use of the VH3-21 gene in mutat...

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