Spiroindolone KAE609 for Falciparum and Vivax Malaria

J. White, Nicholas; Pukrittayakamee, Sasithon; Pyae Phyo, Aung; Rueangweerayut, Ronnatrai; Nosten, François; Jittamala, Podjanee; Jeeyapant, Atthanee; Prakash Jain, Jay; Lefèvre, Gilbert; Li, Ruobing; Magnusson, Baldur; T. Diagana, Thierry; Joel Leong, F.

doi:10.1056/nejmoa1315860

Public

Spiroindolone KAE609 for Falciparum and Vivax Malaria

Published in New England Journal of Medicine • Jul 30, 2014

Authors:

Nicholas J. White

Sasithon Pukrittayakamee

Aung Pyae Phyo

Abstract

BACKGROUND: KAE609 (cipargamin; formerly NITD609, Novartis Institute for Tropical Diseases) is a new synthetic antimalarial spiroindolone analogue with potent, dose-dependent antimalarial activity against asexual and sexual stages of Plasmodium falciparum. METHODS: We conducted a phase 2, open-label...

Subject

Interquartile range

Malaria

Medicine

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