Spiroindolone KAE609 for falciparum and vivax malaria.

NJ, White; S, Pukrittayakamee; AP, Phyo; R, Rueangweerayut; F, Nosten; P, Jittamala; A, Jeeyapant; JP, Jain; G, Lefèvre; R, Li; B, Magnusson; TT, Diagana; FJ, Leong

doi:10.1056/nejmoa1315860

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Spiroindolone KAE609 for falciparum and vivax malaria.

Shared by NobleBlocks on Jul 1, 2014 • 12:00 AM UTC

Authors:

White NJ

Pukrittayakamee S

Phyo AP

Abstract

Background KAE609 (cipargamin; formerly NITD609, Novartis Institute for Tropical Diseases) is a new synthetic antimalarial spiroindolone analogue with potent, dose-dependent antimalarial activity against asexual and sexual stages of Plasmodium falciparum.Methods We conducted a phase 2, open-label st...

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