IL-17–dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants

J. Burlingham, William; B. Love, Robert; Jankowska−Gan, Ewa; D. Haynes, Lynn; Xu, Qingyong; L. Bobadilla, Joseph; C. Meyer, Keith; S. Hayney, Mary; K. Braun, Ruedi; S. Greenspan, Daniel; Gopalakrishnan, Bagavathi; Cai, Junchao; Brand, David; Yoshida, Shigetoshi; W. Cummings, Oscar; S. Wilkes, David

doi:10.1172/jci28031

Public

IL-17–dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants

Published in Journal of Clinical Investigation • Oct 25, 2007

Authors:

William J. Burlingham

Robert B. Love

Ewa Jankowska−Gan

Abstract

Bronchiolitis obliterans syndrome (BOS), a process of fibro-obliterative occlusion of the small airways in the transplanted lung, is the most common cause of lung transplant failure. We tested the role of cell-mediated immunity to collagen type V [col(V)] in this process. PBMC responses to col(II) a...

Subject

Alloimmunity

Bronchiolitis obliterans

Immunology

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