Radiosensitizing Effect of YM155, a Novel Small-Molecule Survivin Suppressant, in Non–Small Cell Lung Cancer Cell Lines

Iwasa, Tsutomu; Okamoto, Isamu; Suzuki, Minoru; Nakahara, Takahito; Yamanaka, Kentaro; Hatashita, Erina; Yamada, Yuki; Fukuoka, Masahiro; Ono, Koji; Nakagawa, Kazuhiko

doi:10.1158/1078-0432.ccr-08-0468

Public

Radiosensitizing Effect of YM155, a Novel Small-Molecule Survivin Suppressant, in Non–Small Cell Lung Cancer Cell Lines

Published in Clinical Cancer Research • Oct 15, 2008

Authors:

Tsutomu Iwasa

Isamu Okamoto

Minoru Suzuki

Abstract

PURPOSE: Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We have now investigated the effect of YM155, a small-molecule inhibitor of survivin expression, on the sensitivity of human non-small cell lung cancer (NSCLC) cell lines to gamma-ra...

Subject

Survivin

Clonogenic assay

Cancer research

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