The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis

M. Strieter, Robert; J. Polverini, Peter; L. Kunkel, Steven; A. Arenberg, Douglas; D. Burdick, Marie; Kasper, James; Dzuiba, Judith; Van Damme, Jo; Walz, Alfred; Marriott, David; Chan, Sham-Yuen; Roczniak, Steven; B. Shanafelt, Armen

doi:10.1074/jbc.270.45.27348

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The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis

Published in Journal of Biological Chemistry • Nov 1, 1995

Authors:

Robert M. Strieter

Peter J. Polverini

Steven L. Kunkel

Abstract

In this study, we demonstrate that the CXC family of chemokines displays disparate angiogenic activity depending upon the presence or absence of the ELR motif. CXC chemokines containing the ELR motif (ELR-CXC chemokines) were found to be potent angiogenic factors, inducing both in vitro endothelial ...

Subject

Monokine

Chemokine

Angiogenesis

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