Effects of the Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor Avasimibe on Human Atherosclerotic Lesions

Tardif, Jean‐Claude; Grégoire, Jean; L. L’Allier, Philippe; J. Anderson, Todd; F. Bertrand, Olivier; Reeves, François; Title, Lawrence; Alfonso, Fernándo; Schampaert, Érick; Hassan, Alita; McLain, Richard; L. Pressler, Milton; Ibrahim, Réda; Lespérance, Jacques; Blue, John; Heinonen, Therèse; Rodés‐Cabau, Josep

doi:10.1161/01.cir.0000147777.12010.ef

Public

Effects of the Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor Avasimibe on Human Atherosclerotic Lesions

Published in Circulation • Nov 9, 2004

Authors:

Jean‐Claude Tardif

Jean Grégoire

Philippe L. L’Allier

Abstract

BACKGROUND: Inhibition of the acyl coenzyme A:cholesterol acyltransferase (ACAT) enzyme may prevent excess accumulation of cholesteryl esters in macrophages. The ACAT inhibitor avasimibe was shown to reduce experimental atherosclerosis. This study was designed to investigate the effects of avasimibe...

Subject

Medicine

Placebo

Intravascular ultrasound

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