A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

W. C. Tang, Walfred; Dietmann, Sabine; Irie, Naoko; G. Leitch, Harry; I. Floros, Vasileios; R. Bradshaw, Charles; A. Hackett, Jamie; F. Chinnery, Patrick; Azim Surani, M.

doi:10.1016/j.cell.2015.04.053

Public

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

Published in Cell • Jun 1, 2015

Authors:

Walfred W. C. Tang

Sabine Dietmann

Naoko Irie

Abstract

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development. We show that the transcriptional program of hPGCs is distinct from that in mice, with co-expression of somatic specifiers and naive pluripotency genes TFCP2L1 and KLF4. This unique gene regulatory network,...

Subject

Biology

Reprogramming

DNA demethylation

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