Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative

C. Fonarow, Gregg; Zhao, Xin; E. Smith, Eric; L. Saver, Jeffrey; J. Reeves, Mathew; L. Bhatt, Deepak; Xian, Ying; F. Hernandez, Adrian; D. Peterson, Eric; H. Schwamm, Lee

doi:10.1001/jama.2014.3203

Public

Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative

Published in JAMA • Apr 22, 2014

Authors:

Gregg C. Fonarow

Xin Zhao

Eric E. Smith

Abstract

IMPORTANCE: The benefits of intravenous tissue plasminogen activator (tPA) in patients with acute ischemic stroke (AIS) are time dependent and guidelines recommend a door-to-needle (DTN) time of 60 minutes or less. However, studies have found that less than 30% of US patients are treated within this...

Subject

Medicine

Interquartile range

Tissue plasminogen activator

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