Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

Kamei, Nozomu; Tobe, Kazuyuki; Suzuki, Ryo; Ohsugi, Mitsuru; Watanabe, Taku; Kubota, Naoto; Ohtsuka-Kowatari, Norie; Kumagai, Katsuyoshi; Q. Sakamoto, Kentaro; Kobayashi, Masatoshi; Yamauchi, Toshimasa; Ueki, Kohjiro; Oishi, Yumiko; Nishimura, Satoshi; Manabe, Ichiro; Hashimoto, Haruo; Ohnishi, Yasuyuki; Ogata, Hitomi; Tokuyama, Kumpei; Tsunoda, Masaki; Ide, Tomohiro; Murakami, Koji; Nagai, Ryozo; Kadowaki, Takashi

doi:10.1074/jbc.m601284200

Public

Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

Published in Journal of Biological Chemistry • Jun 30, 2006

Authors:

Nozomu Kamei

Kazuyuki Tobe

Ryo Suzuki

Abstract

Adipose tissue expression and circulating concentrations of monocyte chemoattractant protein-1 (MCP-1) correlate positively with adiposity. To ascertain the roles of MCP-1 overexpression in adipose, we generated transgenic mice by utilizing the adipocyte P2 (aP2) promoter (aP2-MCP-1 mice). These mic...

Subject

Internal medicine

Adipose tissue

Endocrinology

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