Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

Takeda, Kazuyoshi; J. Smyth, Mark; Cretney, Erika; Hayakawa, Yoshihiro; Kayagaki, Nobuhiko; Yagita∥, Hideo; Okumura, Ko

doi:10.1084/jem.20011171

Public

Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

Published in The Journal of Experimental Medicine • Jan 14, 2002

Authors:

Kazuyoshi Takeda

Mark J. Smyth

Erika Cretney

Abstract

Natural killer (NK) cells and interferon (IFN)-gamma have been implicated in immune surveillance against tumor development. Here we show that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell-mediated and IFN-gamma-dependent tumor surveillance. Admi...

Subject

Tumor necrosis factor alpha

Immune system

Monoclonal antibody

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