Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule

Bottino, Cristina; Castriconi, Roberta; Pende, Daniela; Rivera, Paola; Nanni, Marina; Carnemolla, Barbara; Cantoni, Claudia; Grassi, Jessica; Marcenaro, Stefania; Reymond, Nicolas; Vitale, Massimo; Moretta, Lorenzo; Lopez, Marc; Moretta, Alessandro

doi:10.1084/jem.20030788

Public

Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule

Published in The Journal of Experimental Medicine • Aug 11, 2003

Authors:

Cristina Bottino

Roberta Castriconi

Daniela Pende

Abstract

Human natural killer (NK) cells express a series of activating receptors and coreceptors that are involved in recognition and killing of target cells. In this study, in an attempt to identify the cellular ligands for such triggering surface molecules, mice were immunized with NK-susceptible target c...

Subject

Nectin

Transfection

Cytotoxicity

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