Protection of Humans against Malaria by Immunization with Radiation‐AttenuatedPlasmodium falciparumSporozoites

L. Hoffman, Stephen; M. L. Goh, Lucy; Luke, Thomas; Schneider, Imogene; P. Le, Thong; L. Doolan, Denise; B. Sacci, John; De La Vega, Patricia; Dowler, Megan; Paul, Chris; M. Gordon, Daniel; A. Stoute, José; W. Preston Church, L.; Sedegah, Martha; Gray Heppner, D.; Ripley Ballou, W.; L. Richie, Thomas

doi:10.1086/339409

Public

Protection of Humans against Malaria by Immunization with Radiation‐AttenuatedPlasmodium falciparumSporozoites

Published in The Journal of Infectious Diseases • Apr 15, 2002

Authors:

Stephen L. Hoffman

Lucy M. L. Goh

Thomas Luke

Abstract

During 1989-1999, 11 volunteers were immunized by the bites of 1001-2927 irradiated mosquitoes harboring infectious sporozoites of Plasmodium falciparum (Pf) strain NF54 or clone 3D7/NF54. Ten volunteers were first challenged by the bites of Pf-infected mosquitoes 2-9 weeks after the last immunizati...

Subject

Immunization

Plasmodium falciparum

Malaria

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