Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary Fibrosis

P. Baran, Christopher; M. Opalek, Judy; McMaken, Sara; A. Newland, Christie; M. O’Brien, James; Hunter, Melissa; Bringardner, Benjamin; M. Monick, Martha; R. Brigstock, David; C. Stromberg, Paul; W. Hunninghake, Gary; B. Marsh, Clay

doi:10.1164/rccm.200609-1279oc

Public

Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary Fibrosis

Published in American Journal of Respiratory and Critical Care Medicine • Apr 12, 2007

Authors:

Christopher P. Baran

Judy M. Opalek

Sara McMaken

Abstract

RATIONALE: An increase in the number of mononuclear phagocytes in lung biopsies from patients with idiopathic pulmonary fibrosis (IPF) worsens prognosis. Chemokines that recruit mononuclear phagocytes, such as CC chemokine ligand 2 (CCL2), are elevated in bronchoalveolar lavage (BAL) fluid (BALF) fr...

Subject

Bronchoalveolar lavage

Medicine

Pulmonary fibrosis

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