Equivalence Trial of Melarsoprol and Nifurtimox Monotherapy and Combination Therapy for the Treatment of Second‐Stage <i>Trypanosoma brucei gambiense</i> Sleeping Sickness

Bisser, Sylvie; N’Siesi, François‐Xavier; Lejon, Veerle; Preux, Pierre‐Marie; Van Nieuwenhove, Simon; Miaka Mia Bilenge, Constantin; Büscher, Philippe

doi:10.1086/510534

Public

Equivalence Trial of Melarsoprol and Nifurtimox Monotherapy and Combination Therapy for the Treatment of Second‐Stage Trypanosoma brucei gambiense Sleeping Sickness

Published in The Journal of Infectious Diseases • Jan 4, 2007

Authors:

Sylvie Bisser

François‐Xavier N’Siesi

Veerle Lejon

Abstract

BACKGROUND: Treatment of second-stage sleeping sickness relies mainly on melarsoprol. Nifurtimox has been successfully used to cure melarsoprol-refractory sleeping sickness caused by Trypanosoma brucei gambiense infection. METHODS: An open, randomized trial was conducted to test for equivalence betw...

Subject

Nifurtimox

African trypanosomiasis

Trypanosoma brucei

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