Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O
                    <sub>2</sub>
                    -Regulated Prolyl Hydroxylation

Jaakkola, Panu; R. Mole, David; Tian, Ya-Min; I. Wilson, Michael; Gielbert, Janine; J. Gaskell, Simon; von Kriegsheim, Alexander; F. Hebestreit, Holger; Mukherji, Mridul; J. Schofield, Christopher; H. Maxwell, Patrick; Christopher W. Pugh, ‡; Peter J. Ratcliffe, ‡

doi:10.1126/science.1059796

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Shared by NobleBlocks on Apr 20, 2001 • 12:00 AM UTC

Authors:

Panu Jaakkola

David R. Mole

Ya-Min Tian

Abstract

Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-α subunits are rapidly destroyed by a mechanism that involves ubiquitylation by the von Hippel–Lindau tumor suppressor (pVHL...

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