Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Jaakkola, Panu; R. Mole, David; Tian, Ya‐Min; Wilson, Michael; Gielbert, Adriana; J. Gaskell, Simon; von Kriegsheim, Alex; Hebestreit, Holger; Mukherji, Mridul; J. Schofield, Christopher; H. Maxwell, Patrick; W. Pugh, Christopher; J. Ratcliffe, Peter

doi:10.1126/science.1059796

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

Published in Science • Apr 20, 2001

Authors:

Panu Jaakkola

David R. Mole

Ya‐Min Tian

Abstract

Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-alpha subunits are rapidly destroyed by a mechanism that involves ubiquitylation by the von Hippel-Lindau tumor suppressor (...

Subject

Hydroxylation

Ubiquitin ligase

Chemistry

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