Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus.

Freedman, R; Coon, H; Myles-Worsley, M; Orr-Urtreger, A; Olincy, A; Davis, A; Polymeropoulos, M; Holik, J; Hopkins, J; Hoff, M; Rosenthal, J; C Waldo, M; Reimherr, F; Wender, P; Yaw, J; A Young, D; R Breese, C; Adams, C; Patterson, D; E Adler, L; Kruglyak, L; Leonard, S; Byerley, W

doi:10.1073/pnas.94.2.587

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Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus.

Shared by NobleBlocks on Jan 21, 1997 • 12:00 AM UTC

Authors:

R Freedman

H Coon

M Myles-Worsley

Abstract

Inheritance of a defect in a neuronal mechanism that regulates response to auditory stimuli was studied in nine families with multiple cases of schizophrenia. The defect, a decrease in the normal inhibition of the P50 auditory-evoked response to the second of paired stimuli, is associated with atten...

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