Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

F. Schott, Anne; D. Landis, Melissa; Dontu, Gabriela; A. Griffith, Kent; M. Layman, Rachel; E. Krop, Ian; A. Paskett, Lacey; Wong, Helen; E. Dobrolecki, Lacey; T. Lewis, Michael; M. Froehlich, Amber; Paranilam, Jaya; F. Hayes, Daniel; S. Wicha, Max; C. Chang, Jenny

doi:10.1158/1078-0432.ccr-11-3326

Public

Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

Published in Clinical Cancer Research • Jan 23, 2013

Authors:

Anne F. Schott

Melissa D. Landis

Gabriela Dontu

Abstract

PURPOSE: Accumulating evidence supports the existence of breast cancer stem cells (BCSC), which are characterized by their capacity to self-renew and divide indefinitely and resistance to conventional therapies. The Notch pathway is important for stem cell renewal and is a potential target for BCSC-...

Subject

Docetaxel

Medicine

Breast cancer

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