Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis

K. Semple, Robert; Sleigh, Alison; R. Murgatroyd, Peter; Adams, Claire; Bluck, Les; J. Jackson, Sarah; Vottero, Alessandra; Kanabar, Dipak; Charlton-Menys, Valentine; N. Durrington, Paul; A. Soos, Maria; Adrian Carpenter, T.; J. Lomas, David; Cochran, Elaine; Görden, Phillip; O’Rahilly, Stephen; B. Savage, David

doi:10.1172/jci37432

Public

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis

Published in Journal of Clinical Investigation • Jan 22, 2009

Authors:

Robert K. Semple

Alison Sleigh

Peter R. Murgatroyd

Abstract

Metabolic dyslipidemia is characterized by high circulating triglyceride (TG) and low HDL cholesterol levels and is frequently accompanied by hepatic steatosis. Increased hepatic lipogenesis contributes to both of these problems. Because insulin fails to suppress gluconeogenesis but continues to sti...

Subject

Internal medicine

Insulin resistance

Endocrinology

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