Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.

RK, Semple; A, Sleigh; PR, Murgatroyd; CA, Adams; L, Bluck; S, Jackson; A, Vottero; D, Kanabar; V, Charlton-Menys; P, Durrington; MA, Soos; TA, Carpenter; DJ, Lomas; EK, Cochran; P, Gorden; S, O'Rahilly; DB, Savage

doi:10.1172/jci37432

Public

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.

Shared by NobleBlocks on Jan 26, 2009 • 12:00 AM UTC

Authors:

Semple RK

Sleigh A

Murgatroyd PR

Abstract

Metabolic dyslipidemia is characterized by high circulating triglyceride (TG) and low HDL cholesterol levels and is frequently accompanied by hepatic steatosis. Increased hepatic lipogenesis contributes to both of these problems. Because insulin fails to suppress gluconeogenesis but continues to sti...

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