Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

Foretz, Marc; Ancellin, Nicolas; Andréelli, Fabrizio; Saintillan, Yannick; Grondin, Pascal; Kahn, Axel; Thorens, Bernard; Vaulont, Sophie; Viollet, Benoı̂t

doi:10.2337/diabetes.54.5.1331

Public

Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

Published in Diabetes • May 1, 2005

Authors:

Marc Foretz

Nicolas Ancellin

Fabrizio Andréelli

Abstract

AMP-activated protein kinase (AMPK) is a major therapeutic target for the treatment of diabetes. We investigated the effect of a short-term overexpression of AMPK specifically in the liver by adenovirus-mediated transfer of a gene encoding a constitutively active form of AMPKalpha2 (AMPKalpha2-CA). ...

Subject

AMPK

Lipogenesis

AMP-activated protein kinase

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