Enzyme-Linked Immunosorbent Assay Specific to Dengue Virus Type 1 Nonstructural Protein NS1 Reveals Circulation of the Antigen in the Blood during the Acute Phase of Disease in Patients Experiencing Primary or Secondary Infections

Alcon, Sophie; Talarmin, Antoine; Debruyne, Monique; K. Falconar, Andrew; Deubel, Vincent; Flamand, Marie

doi:10.1128/jcm.40.02.376-381.2002

Public

Enzyme-Linked Immunosorbent Assay Specific to Dengue Virus Type 1 Nonstructural Protein NS1 Reveals Circulation of the Antigen in the Blood during the Acute Phase of Disease in Patients Experiencing Primary or Secondary Infections

Published in Journal of Clinical Microbiology • Feb 1, 2002

Authors:

Sophie Alcon

Antoine Talarmin

Monique Debruyne

Abstract

During flavivirus infection in vitro, nonstructural protein NS1 is released in a host-restricted fashion from infected mammalian cells but not vector-derived insect cells. In order to analyze the biological relevance of NS1 secretion in vivo, we developed a sensitive enzyme-linked immunosorbent assa...

Subject

Dengue fever

Virology

Dengue virus

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