Human Lymphoid and Myeloid Cell Development in NOD/LtSz-
                    <i>scid IL2R</i>
                    γ
                    <i>null</i>
                    Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

D Shultz, Leonard; L Lyons, Bonnie; M Burzenski, Lisa; Gott, Bruce; Chen, Xiaohua; Chaleff, Stanley; Kotb, Malak; D Gillies, Stephen; King, Marie; Mangada, Julie; L Greiner, Dale; Handgretinger, Rupert

doi:10.4049/jimmunol.174.10.6477

Public

Human Lymphoid and Myeloid Cell Development in NOD/LtSz- scid IL2R γ null Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

Shared by NobleBlocks on May 1, 2005 • 12:00 AM UTC

Authors:

Leonard D Shultz

Bonnie L Lyons

Lisa M Burzenski

Abstract

Abstract Ethical considerations constrain the in vivo study of human hemopoietic stem cells (HSC). To overcome this limitation, small animal models of human HSC engraftment have been used. We report the development and characterization of a new genetic stock of IL-2R common γ-chain deficient NOD/LtS...

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