Transcriptional Repression by the Retinoblastoma Protein through the Recruitment of a Histone Methyltransferase

The E2F transcription factor controls the cell cycle-dependent expression of many S-phase-specific genes. Transcriptional repression of these genes in G(0) and at the beginning of G(1) by the retinoblasma protein Rb is crucial for the proper control of cell proliferation. Rb has been proposed to fun... View More