Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types

Ossovskaya, Valeria; Chou Koo, Ingrid; Kaldjian, Eric; Alvares, C.; M. Sherman, Barry

doi:10.1177/1947601910383418

Public

Upregulation of Poly (ADP-Ribose) Polymerase-1 (PARP1) in Triple-Negative Breast Cancer and Other Primary Human Tumor Types

Published in Genes & Cancer • Aug 1, 2010

Authors:

Valeria Ossovskaya

Ingrid Chou Koo

Eric Kaldjian

Abstract

Poly (ADP-ribose) polymerase-1 (PARP1) is a key facilitator of DNA repair and is implicated in pathways of tumorigenesis. PARP inhibitors have gained recent attention as rationally designed therapeutics for the treatment of several malignancies, particularly those associated with dysfunctional DNA r...

Subject

Downregulation and upregulation

Cancer research

Triple-negative breast cancer

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