Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

Brad Jones, R.; C. Ndhlovu, Lishomwa; D. Barbour, Jason; M. Sheth, Prameet; R. Jha, Aashish; Long, Brian; C. Wong, Jessica; Satkunarajah, Malathy; Schweneker, Marc; M. Chapman, Joan; Gyenes, Gábor; Vali, Bahareh; Hyrcza, Martin; Yun Yue, Feng; Kovacs, Colin; Sassi, Aref; Loutfy, Mona; Halpenny, Roberta; Persad, Desmond; Spotts, Gerald; Hecht, Frederick; Chun, Tae‐Wook; M. McCune, Joseph; Kaul, Rupert; M. Rini, James; F. Nixon, Douglas; Ostrowski, Mario

doi:10.1084/jem.20081398

Public

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

Published in The Journal of Experimental Medicine • Nov 10, 2008

Authors:

R. Brad Jones

Lishomwa C. Ndhlovu

Jason D. Barbour

Abstract

Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population of dysfunctional T cells marked by surface expression of the glycoprotein Tim-3. The frequency of this population was increased in HIV-1-infe...

Subject

Biology

CD38

Immunology

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