Relationship of BMPR2 Mutations to Vasoreactivity in Pulmonary Arterial Hypertension

Gregory Elliott, C.; W. Glissmeyer, Eric; T. Havlena, Gregory; F. Carlquist, John; T. McKinney, Jason; Rich, Stuart; D. McGoon, Michael; Beth Scholand, Mary; Kim, Miryoung; L. Jensen, Robert; W. Schmidt, Jon; Ward, Kenneth

doi:10.1161/circulationaha.105.601930

Public

Relationship of BMPR2 Mutations to Vasoreactivity in Pulmonary Arterial Hypertension

Published in Circulation • May 22, 2006

Authors:

C. Gregory Elliott

Eric W. Glissmeyer

Gregory T. Havlena

Abstract

BACKGROUND: Vasoreactivity tests are fundamental in evaluating pulmonary arterial hypertension (PAH). Mutations of the transforming growth factor-beta type II receptor gene, BMPR2, predispose to the development of pulmonary hypertension and may alter the response to vasodilators. Previous investigat...

Subject

Nonsynonymous substitution

BMPR2

Medicine

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