A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β<sup>−</sup>-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

Müller, Cristina; Zhernosekov, Konstantin; Köster, U.; Johnston, K.; Dorrer, Holger; Höhn, Alexander; T. van der Walt, Nico; Türler, Α.; Schibli, Roger

doi:10.2967/jnumed.112.107540

Public

A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β−-Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

Published in Journal of Nuclear Medicine • Nov 8, 2012

Authors:

Cristina Müller

Konstantin Zhernosekov

U. Köster

Abstract

UNLABELLED: Terbium offers 4 clinically interesting radioisotopes with complementary physical decay characteristics: (149)Tb, (152)Tb, (155)Tb, and (161)Tb. The identical chemical characteristics of these radioisotopes allow the preparation of radiopharmaceuticals with identical pharmacokinetics use...

Subject

Terbium

In vivo

Radiochemistry

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